Remodeling the Cancer Angiogenesis by Nanoparticles: A novel approach to Cancer Treatment

Abstract

Cancer is one of the most life-threating as well as deadly diseases with uncontrolled, uncoordinated cell division. Neoplasm is a mass of tumor cells that are not invasive but after it becomes malignant form, it is exceedingly difficult to eradicate. Cancer causation is mainly due to several factors such as genetic, occupational, way of life, chemical carcinogens, different artificial food additives, toxins, chronic infections of many pathogens, and other environmental factors. Notwithstanding, there is a massive range of cancer therapies, due to the many obstacles and resistance of the tumor cells it could not be able to get an efficient outcome. In past decades most of those therapies were focused on tumor cells alone. However, many documentations undoubtedly have shown that the tumor microenvironment has a greater influence on this complex localized disease. The tumor microenvironment consists of an enormous range of cells and non-cellular components. As a profitable nature, numerous studies have experimentally shown the efficiency of nanotechnology-based cancer therapies. The remodeling of the cancer microenvironment by nanoparticles (NP) is one efficacious strategy for the treatment of cancer. Most of them have shown enormous outcomes in-vivo and some of them are under preclinical trials. This review mainly focuses on a novel treatment that is associated with NP by targeting the remodeling angiogenesis of the tumor. Angiogenesis is the process of the emergence of new blood vessels from early blood vessels and it plays a major role in the pathologic and physiologic processes of cancer development. Therefore, the main objective of this review is the identification of strategies for cancer treatment mainly focusing on angiogenesis of the tumor microenvironment.