Glutathione Encapsulated Liposomes for Efficient Delivery in Pharmaceutical and Cosmeceutical Products

Abstract

The present study focuses on a simple yet effective approach to synthesizing glutathione (GSH) encapsulated liposomes and further discusses its potential applications of it. The modified ethanol injection method and the reverse-phased evaporation method were performed to find a suitable method of synthesis. Characterization techniques suchas High Performance Liquid Chromatography (HPLC) and the Particle Size Analyzer (PSA) were utilized for the verification of glutathione encapsulation and to identify the average particle size and the Polydispersity Index (PDI), as these factors play a main role in the efficacy of different applications. The results obtained report the encapsulation of glutathione and a particle size of 86.14 nm and PDI of 0.132 suggesting the formation of small unilamellar vesicles (SUVs) containing glutathione.