Weighted Gene Co-expression Network Analysis to Identify Key Modules and Hub Genes Related to Withanoloides Biosynthesis Pathway in Datura metel

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dc.contributor.authorHewadikaram, M.
dc.contributor.authorDe Silva, K.
dc.date.accessioned2023-09-07T06:36:06Z
dc.date.available2023-09-07T06:36:06Z
dc.date.issued2022-11-25
dc.description.abstractThe gene co-expression analysis and clustering concept were utilized to identify possible genes present in the withanolides biosynthesis pathway. Weighted Gene Co-expression Network Analysis (WCGNA) was carried out to identify putative genes. The identified known genes were used as bait to locate the co-expressed genes among them in identified modules in WGCNA analysis. As cytochrome P450s and glycosyltransferase (UGT) are candidates for withanolide biosynthesis in the literature, the study was focused on identifying CYPs and UGT genes. Finally, the study was able to locate 6 CYP genes and 1 UGT gene as putative candidate genes involved in the withanolides biosynthesis pathway. However, in silico characterization should be carried out for further isolation processes.
dc.identifier.citationHewadikaram,M., De Silva, K. (2022) , Weighted Gene Co-expression Network Analysis to Identify Key Modules and Hub Genes Related to Withanoloides Biosynthesis Pathway in Datura metel International Conference On Business Innovation (ICOBI), NSBM Green University , Sri Lanka. P. 478-485
dc.identifier.urihttps://nspace.nsbm.ac.lk/handle/123456789/243
dc.language.isoen
dc.publisherNsbm Green University
dc.titleWeighted Gene Co-expression Network Analysis to Identify Key Modules and Hub Genes Related to Withanoloides Biosynthesis Pathway in Datura metel
dc.typeArticle
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